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Marco Marchetti

Marco Marchetti

University of Rome Tor Vergata, Italy

Title: Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications

Biography

Biography: Marco Marchetti

Abstract

Introduction:The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition and resting energy expenditure (REE) in the short term reversal of diabetes mellitus Type 2 (DMT2).
Material and Methods:
For eight weeks, subjects were administered a personalized VLCKD with protein intake based on lean mass and synthetic amino acidic protein supplementation. Each subject was assessed by anthropometry, Dual-energy X-ray Absorptiometry (DXA), bio impedentiometric analysis (BIA), indirect calorimetry, and biochemical analysis.
Results:  The main findings were the saving of lean mass, the reduction of abdominal fat mass, restored metabolic flexibility, the maintenance of resting energy expenditure, and the reversion of diabetes.
Conclusion: In the process of DMT2 reversion, the main results obtained from this exploratory study on body composition and REE changes are represented by the predominant reduction of abdominal fat mass, the saving of lean mass, and the reduction of fasting glycaemia and glycated hemoglobin. An acute weight loss occurred uniformly in the 20 patients who underwent eight weeks of VLCKD. Despite the rigidity of the nutritional treatment, we recorded 100% compliance. Therefore, we hypothesize that saving the lean mass and maintaining the REE will allow us to obtain long-term success, especially after a treatment that attacks visceral fat. These results highlight how the application of preventive, predictive, personalized, and participative medicine to nutrition maybe promising for the prevention of diabetes and enhancement of obesity treatment.