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González-Hedström, Daniel

. Pharmactive Biotech Products S.L. (Spain)

Title: Comparison of Antioxidant Activity of Different Standardized Plant Extracts: saffron (Crocus sativus L.) stigmas and aged garlic (Allium sativum) extracts

Biography

Biography: González-Hedström, Daniel

Abstract

Oxidative stress is the major cause for which many chronic and degenerative diseases occur1. Among them, aging, atherosclerosis, ischemic heart disease, neurodegenerative diseases and cancer are included2. It is known that the action of the harmful free radicals which cause the oxidative stress can be blocked by antioxidant substances, which contain scavenging activity and produces the detoxification of the organism. Nowadays, it has been known that several plant extracts contain antioxidant activity, using them as a source of antioxidants to eliminate free radicals3,4. Thus, the aim of this study was the evaluation of the antioxidant activity of different saffron (Crocus sativus L.) stigma extracts (SE), as antioxidants for neurodegenerative disease prevention, and garlic (Allium sativum) and red yeast rice extracts, as antioxidants for the cardiovascular disease prevention. On the one hand, the antioxidant activity of two different SE, Spanish SE (affron®) and Iranian SE (ISE) were compared. On the other hand, two short-term aged black garlic extracts (ABG10+® and ABG10+®organic), one long-term aged garlic extract (LTAG) and one red yeast rice extract (RYR) were compared. The antioxidant capacity measure was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay as described by Parejo et al. 20025. The IC50 of the % of DPPH oxidation inhibition was used to compare the antioxidant capacity of the different extracts. Nearly a 2-fold higher IC50 value was obtained for affron® compared to ISE, and nearly a 10-fold higher and 2-fold higher IC50 values were obtained for ABG10+® and ABG10+®organic compared to LTAG and RYR extract correspondingly.

In conclusion, affron® has been shown to have more antioxidant capacity than ISE. While ABG10+® and ABG10+®organic, has been shown to have more antioxidant capacity than LTAG and RYR. Therefore, affron® and ABG10+® would provide higher antioxidant activity for neurodegenerative and cardiovascular disease prevention respectively.